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The blast happened just before noon, sparking a two-alarm fire at the Hibernia Road home in West Brandywine Township, NBC Philadelphia reports.
Two of the children were airlifted to area hospitals while the other two children were taken by EMS with unknown injuries, officials told the news outlet.
Nearly two dozen fire and rescue companies responded to the scene from Berks, Chester and Lehigh counties.
Click here for the full report by NBC Philadelphia.
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